Laboratory of Immunology

Competences

Main axes of research

  • Surveillance of new emerging viruses and genotypic variants
  • Genetic and antigenic diversity of human and veterinary viruses
  • Molecular evolution and pathogenicity of influenza viruses in human, avian and swine
  • Immunisation strategies against viruses and environmental risk factors (e.g. carcinogens)
  • Gene structure, transcriptional and translational regulations of the glucocorticoid receptor (and other nuclear receptors) and its role as a major stress in response mediator
  • Epigenetic perinatal programming of the immune system

Current research projects

A. Genetic and phenotypic diversity of virus

A.1 Measles

A.2. Other fever rash viruses (Rubella, Parvovirus)

A.3 Hep B

A.4 Human Influenza

A.5 Avian Influenza

A.6 Newcastle Disease virus (NDV)

A.7 Infectious Bronchitis Virus (IBV)

A.8 Tick-born pathogens

A.9 Norovirus

B. Vaccination strategy against chemical carcinogenesis

C. Neuroendocrine immunology

D. Proteomics

E. Perinatal Programming of the Immune System

Resources and collaborations

Equipment

  • 2-D DIGE technology for the separation and differential protein expression profiling
  • 2-D Multi-fluorescence scanner (Typhoon)
  • Automated protein digester
  • Protein identification by matrix assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF)
  • LC-electrospray mass spectrometry (Iontrap)
  • Biosafety level 3 laboratory
  • SPF animal facility
  • Molecular biology equipment
  • Cell culture laboratories
  • Multiple peptide synthesis and analysis

Products and services

Reference activities:

  • National Reference Laboratory for Measles and Rubella
  • National Reference Laboratory Activities for Avian, Human, Swine Influenza
  • World Health Organisation Collaborating Centre for Reference and Research on Measles Infections
  • World Health Organisation European Reference Centre for Measles and Rubella

Development of reagents:

  • Multiple peptides synthesis and analysis
  • Monoclonal/polyclonal antibodies
  • Recombinant proteins
  • Production of viral antigen

Scientific services:

  • Proteomics analysis, analysis of translational modifications of proteins.
  • Analysis of synthetic peptides (mass spectrometry, high pressure liquid chromatography
  • Maintenance of specific pathogen free mice

Major partnerships and collaborations

The department has various mainly academic collaborations all over the world.

Some of the company contacts are listed here:

  • PAB Productions, Hebertshausen (DE): diagnostic strategies
  • Biognosis, Jülich (DE): diagnostics
  • Biomer, Krailling (DE): diagnostic strategies
  • LDN, Nordhorn (DE): diagnostics
  • NUNC, Roskilde (DK): diagnostic strategies
  • M-Scan Ltd, Ascot (UK): MS analysis of peptides
  • AC Biotech, Jülich (DE): diagnostic strategies
  • Serum Insitute of India, Pune (IN): development of vaccine strategies
  • SmithKline Beecham, Rixensart (BE): molecular biology of the MV H protein
  • Erilab, Kuopio (FI): diagnostic test

Human resources

  • 8 Researchers (Prof., ass. Prof., Post-docs, PhD)
  • 12 Doctoral students and students
  • 0 Engineers
  • 8 Technicians
  • 23 Other

Business sector(s)

  • Life Sciences, health and biotechnology

Intellectual property

Patent

Title : Peptides corresponding or imitating at least one antigenic determinant of the hamagglutinin protein of mobillivirus

Registration : 26-07-1997 - N° PCT/EP97/04070

Applicant(s) : Muller Claude

Inventor(s) :

  • First inventor : Muller Claude

Patent

Title : Detection of measles virus-specific antibodies using recombinant measles virus glycoprotein

Registration : 01-09-1997 - N° PCT/EP98/005546

Applicant(s) : Muller Claude and Bouche Fabienne

Inventor(s) :

  • First inventor : Bouche Fabienne

Contact

Laboratory of Immunology
20A, rue Auguste Lumière, L-1950 Luxembourg
Luxembourg
Phone: +352 49 06 04 22 0
Fax: +352 49 06 86
Email: claude.muller@lns.etat.lu
Site: http://www.lih.lu

R&D Contact

Prof. Dr. MULLER Claude P.
Head of Research Unit
Phone: +352 49 06 04
Email: claude.muller@lns.etat.lu

  • Updated 29-06-2015