Neuroinflammation

Competences

Main axes of research

The group is investigating the molecular mechanisms of inflammation and differentiation of glial cells that are relevant during neurodegenerative and inflammatory events of the brain.

Using cell and molecular biology approaches, the objective of the team is to gain further insight into the pathophysiological events taking place during the onset and chronification of inflammatory reactions in the CNS during neurodegenerative diseases like Alzheimer’s disease or Parkinson’s disease. The influence of typical neuroectodermal differentiation pathways (like the Notch pathway) as well as the effect of metabolic stress (via nuclear receptors) on this phenotype acquisition is analysed. An important issue during lesion-induced chronic stress in the brain is the interplay between activated glial cells (astrocytes and microglia) and the neural progenitor cells, which have the potential to repair the lesioned areas. The signalling events happening during the dialog between these cell types are studied. The implication of the Notch pathway in the activation of astrocytes and microglia is studied. A pharmacochemical approach is accompanying the basic research efforts in order to define molecular structures able to modulate the biological responses. We are also developing the thematic of inflammasome in neuroinflammation and neurodegeneration.

Current research projects

In the framework of a FNR CORE project, we have shown that the inhibition of the Notch pathway, through Jagged1 down-regulation, induces a decrease of expression in various elements characteristic of inflammation and gliosis, which should favour an endogenous self-repair potential of the central nervous system during brain insults or neurodegenerative diseases. The team also further characterised the microglial phenotype under specific pro-and anti-inflammatory conditions. We are also investigating the dedifferentiation capacity of the glial cells and especially the astrocytes during an inflammatory reaction. In fact, understanding these processes of dedifferentiation processes could be an important issue to develop regenerative therapies.

Resources and collaborations

Equipment

  • Quantitative-PCR
  • Immunoblotting
  • Cell culture facility
  • Animal housing
  • Fluorescence microscopy, confocal microscopy (common research unit facility)
  • Flow cytometry (common research unit facility)

Products and services

Information not available

Major partnerships and collaborations

National: CRP-Santé, Microarray Centre; Axoglia Therapeutics

International: Centre for the Cellular Basis and Behaviour, Department of Neuroscience, King’s College London (UK); Department of Biotechnology, Faculty of Applied Computer Sciences and Microsystems Technology, University of Applied Sciences Kaiserslautern (DE)

Human resources

  • 7 Researchers (Prof., ass. Prof., Post-docs, PhD)
  • 5 Doctoral students and students
  • 0 Engineers
  • 1 Technicians
  • 0 Other

Business sector(s)

  • Life Sciences, health and biotechnology

Intellectual property

Patent

Title : Dérivés de tocophérol à longue chaîne hydroxylée utiles comme neurotrophiques

Registration : 24-09-2004 - N° PCT/FR2004/002424

Applicant(s) : Université Louis Pasteur, Strasbourg (FR) Centre National de la Recherche Scientifique, Université du Luxembourg

Inventor(s) :

  • First inventor : LUU Bang
  • Second inventor : HEUSCHLING Paul
  • Other inventor(s) : MULLER Thierry; MORGA Eleonora

Patent

Title : Dérivé de resveratrol à longue chaîne hydroxylée utiles comme neurothrophiques

Registration : 02-03-2007 - N° PCT/EP2007/051994

Applicant(s) : Centre National de la Recherche Scientifique Université du Luxembourg

Inventor(s) :

  • First inventor : LUU Bang
  • Second inventor : HAUSS Frédérique
  • Other inventor(s) : COOWAR Djalil; LIU Jiawei; HEUSCHLING Paul; MORGA Eleonora; GRANDBARBE Luc; MICHELUCCI Alessandro

Contact

Neuroinflammation
Campus Limpertsberg, 162a, avenue de la Faiencerie, L-1511 Luxembourg
Luxembourg
Phone: +352 46 66 44 63 75
Fax: +352 46 66 44 63 71
Email: eleonora.morga@uni.lu
Site: http://wwwen.uni.lu/research/fstc/life_sciences_research_unit

R&D Contact

PhD HEUSCHLING Paul
Dean/Professor
Phone: +352 46 66 44 63 70
Email: paul.heuschling@uni.lu

R&D Contact

PhD MORGA Eleonora
Associate-Professor
Phone: +352 46 66 44 63 70
Email: eleonora.morga@uni.lu

  • Updated 29-06-2015